Working With Rails

RE: что вы думаете о Ruby on Steel!! Visual Studio 2005-2008

Hamster Burial Kits & 998 Other Business Ideas

Sazcast Episode 13 – Is Ford a Tech Company?

A Jungle Fever Experience

My colleague Ben and I were walking around midtown trying to find a place to eat, seeing as the cafeteria at work is insanely barren due to a previous incident. We were walking towards the corner of 41st St and 7th Ave when some guy yelled at me, “You look good!”

Now, I typically tell men who do this where I think they should go, but the thing is, I was just telling Ben about how I gained a bunch of weight while living in Florida, and seeing as I have lost a lot of it, I turned around and said, “thanks!”

However, the story does not end there. We were waiting to cross the street when the guy ran up to us. I quickly whispered to Ben, “you are my boyfriend!” The guy stood in front of us apologizing profusely. He then asked Ben, “is this your wife?”, totally upping the ante of my meager request. I stood there waiting for Ben to answer, thinking, “please say yes please say yes.”

Ben said yes. Thank you, Ben! The guy then started to go on about how fine I was, and that he was a black man complimenting me. We’re both unsure if he was trying to say that made this situation better or worse, complimenting Ben’s “wife” by cat calling her on the street. We just said, “no worries,” hoping he’d go away.

He finally did, but not before telling Ben, “Don’t screw it up, because I got jungle fever!”

Most Influential Online Marketers of 2009 FAIL

curious about who made the foursquare logo...

Nolan curious about who made the foursquare logo... 10 hours ago from Twitter - Comment - Like

View-Source Is Good? Discuss. | Continuing Intermittent Incoherency

(posted by cardioid)

2010년 1월 11일

• han9kin님 미투데이 아이폰앱에서 혹시 me2api-objc 사용하세요?(me2api objective c client library) #
• 밴드 me2API 가 공개되었습니다. 자세한 내용은 get_bands, get_posts, create_post 문서를 참고하세요(MDN me2API 밴드 더 빨리 오픈 못해서 죄송합니다.) #
• 밴드API 오픈하고 저녁먹고 왔더니 스믈님은 애플리케이션을 업데이트 했다.(MDN 개발자님들께 많이 배웁니다. 진정한 ㄱㄹㅈㅁㄴ) #

이 글은 꽃띠앙님의 2010년 1월 11일의 미투데이 내용입니다.

RE: RE: И так по многочисленным просьбам собираем статистику по популярным джемам и плагинам.

FireQuery = Firebug extension for jQuery development

(posted by vinbarnes)

Festivales, Verano 2010

Erro na exportação SQL do phppgadmin no Ubuntu: invalid option — ‘d’

"He loves [17-year-old protagonist] Bella so much that he runs away from her to protect her. My..."

10 Tips for Becoming a Smarter, Social Business Person

yes, i actually look at the ads on google. in certain domains, they're actually better than the results.

Nolan yes, i actually look at the ads on google. in certain domains, they're actually better than the results. 10 hours ago from Twitter - Comment - Like

Your Daily Cupcake

Congratulations to our friends over at Saint Cupcake for their write-up in Friday’s Daily Candy. Perfect timing for announcing their new Saint Cupcake Takes Flight shop where customers are able to order cupcake decorating kits of 3, 6 or 12 cupcakes (which we coincidentally launched Friday as well).

Rod Blagojevich Interview - Rod Blago Quotes - Esquire

— good times. How much does he love the people of Illinois? Only the people from Chicago the way he ran things. (posted by RIMBoy)

started reading http://is.gd/655K2 but my maths need work. buzz word compliant w/ gravity, newton, & holo principle...waving black holes?

Nolan started reading http://arxiv.org/pdf... but my maths need work. buzz word compliant w/ gravity, newton, & holo principle...waving black holes? 11 hours ago from Twitter - Comment - Like

BinaryAge - tools for developers

Cool stuff there. Check out the finder with tabs. via @defunkt

Turn Your iPhone/iPod Touch Into A WWII Fighter

Bored? Don't worry, here's a new programming language...

Recently – for various degrees of recent that is – people really seem to be into programming language design and development. You’ve probably all heard about Scala, Clojure and Go already, but here are some more new languages which may be new to you (descriptions taken from the projects’ websites):

• ANI, the experimental, high-performance, statically-safe, fully implicitly parallel, object-oriented, general-purpose dataflow programming language.
• CoffeeScript is a little language that compiles into JavaScript. [...] it compiles into clean JavaScript (the good parts) that can use existing JavaScript libraries seamlessly, and passes through JSLint without warnings. The compiled output is quite readable — pretty-printed, with comments preserved intact.
• Factor is a concatenative programming language where references to dynamically-typed values are passed between words (functions) on a stack. [It] is expressive, fast, supports interactive development and has a full-featured library.
• ooc, a modern, object-oriented, functional-ish, high-level, low-level, sexy programming language. It’s translated to pure C with a source-to-source compiler. It strives to be powerful, modular, extensible, portable, yet simple and fast.
• Yeti, ML style functional programming language, that runs on the JVM.

Boah ne, also ich würd' ne Baustelle anders planen. z.B. erstmal mit nem JIRA anfangen. Nervenaufreibend. Aber so richtig jetzt.

Michael Boah ne, also ich würd' ne Baustelle anders planen. z.B. erstmal mit nem JIRA anfangen. Nervenaufreibend. Aber so richtig jetzt. 5 hours ago from Twitter - Comment - Like

Selenium – no display specified

Sleeping Skills (via thedailywhat)

Sleeping Skills (via thedailywhat)

Another dose of Martian awesome | Bad Astronomy | Discover...

Another dose of Martian awesome | Bad Astronomy | Discover Magazine (via lkm)

GP Practice Design looks familiar

This ...

... looks an awful lot like this...

... wouldn‘t you say?

Is this plagiarism? Decide for yourself?

giving echofon another whirl after tweetie. it's more colorful, but can two Twitter clients be any more alike?

Nolan giving echofon another whirl after tweetie. it's more colorful, but can two Twitter clients be any more alike? 11 hours ago from Twitter - Comment - Like

anova

@jqr don't diss the viral marketing. :-)

Nolan @jqr don't diss the viral marketing. :-) 11 hours ago from Twitter - Comment - Like

Technology Council to launch downtown WiFi network - Nashville Business Journal:

(posted by brandonvalentine)

Dispatch From The TE Labs: Vin & Vin vs. The Super Beetle

@robbyslaughter inbox 2676, nothing actionable for today

Nolan @robbyslaughter inbox 2676, nothing actionable for today 11 hours ago from Twitter - Comment - Like

Facebook | Back in my day Vampires sucked blood, not cock.

I must be getting old for agreeing to something starting with “Back in my days”. Or the world is going down the drain very quickly.

@avdi here's a reason not to use sass: http://lesscss.org/

Nolan @avdi here's a reason not to use sass: http://lesscss.org/ 11 hours ago from Twitter - Comment - Like

"up to the minute information" IN A BOOK!! #FIAL

Nolan "up to the minute information" IN A BOOK!! #FIAL 11 hours ago from Twitter - Comment - Like

"the four hour workweek" was expanded and updated post-reading :-/

Nolan "the four hour workweek" was expanded and updated post-reading :-/ 11 hours ago from Twitter - Comment - Like

@littleidea ...rewriting puppet in erlang? chef can't do that. ;-)

Nolan @littleidea ...rewriting puppet in erlang? chef can't do that. ;-) 11 hours ago from Twitter - Comment - Like

Evangelizing Yourself

Honor thy mortgage contract

Mashable.com needs to skew more lightweight - it’s the...

Mashable.com needs to skew more lightweight - it’s the single most processor intensive site I’m aware of. That peak in the graph represents 10-15 seconds of constant 90% to 100% processor usage as the site was loading and playing several instances of flash ads all of which were dropping frames like mad to keep up. The machine in use is a 2.93 Ghz Intel Core 2 Duo Macbook Pro w/ 8 GB RAM, so I weep for lesser machines that try to load Mashable.

@erima discovered this; thought of you. Have any better recc's? http://www.jetpens.com/forum/

Brian Del Vecchio @erima discovered this; thought of you. Have any better recc's? http://www.jetpens.com/forum/ 21 hours ago from Twitter - Comment - Like

RT @DRUNKHULK: SCIENTIST WANT BRING BACK EXTINCT ANIMALS! HAVE THEY NO LEARN ANYTHING FROM TIME THEY BRING BACK CHEVY CHASE! STUPID SCIENCE!

Brian Del Vecchio RT @DRUNKHULK: SCIENTIST WANT BRING BACK EXTINCT ANIMALS! HAVE THEY NO LEARN ANYTHING FROM TIME THEY BRING BACK CHEVY CHASE! STUPID SCIENCE! 21 hours ago from Twitter - Comment - Like

more palindromic fun: 01/11/10!

Nolan more palindromic fun: 01/11/10! 12 hours ago from Twitter - Comment - Like

indiana is now hiring militarized police (aka SWAT) #ads

Nolan indiana is now hiring militarized police (aka SWAT) #ads 12 hours ago from Twitter - Comment - Like

Footprints

DRUNKHULK: SCIENTIST WANT BRING BACK EXTINCT ANIMALS! HAVE THEY NO LEARN ANYTHING FROM TIME THEY BRING BACK CHEVY CHASE! STUPID SCIENCE!

Brian Del Vecchio DRUNKHULK: SCIENTIST WANT BRING BACK EXTINCT ANIMALS! HAVE THEY NO LEARN ANYTHING FROM TIME THEY BRING BACK CHEVY CHASE! STUPID SCIENCE! - http://twitter.com/DRUNKHU... 22 hours ago from Twitter / Favorites from... - Comment - Like

MX Snippets Part 1: Generate Molecular Fingerprints From the Command Line

Molecular fingerprints play an important role in cheminformatics. MX, the high-performance cheminformatics toolkit written in Java, comes complete with the ability to generate molecular fingerprints. This article, the first of a new series discussing MX through compilable snippets of Java code, shows how to interactively test fingerprints in MX through a simple command-line utility.

What the Program Does

From the command line, the program accepts a SMILES string as input and returns the indices of all bits set using the MX PathFingerprinter:

$ java -cp .:mx-1.0-beta-2.jar FPTest
> CCCCC
{185, 293, 595, 742, 927}
> CCCCCC
{185, 293, 338, 595, 742, 927}
> C1CCCCC1 
{185, 194, 293, 338, 595, 742, 927}
> exit

After entering a SMILES string, the program prints out the indices of all of the bits set in a 1024-bit fingerprint. As you can see, each fingerprint in the progression pentane >hexane >cyclohexane is a superset of its predecessors. This is, of course, the feature that makes fingerprints so useful for substructure search.

Note: the MX SMILES parser is only partially implemented at the moment and will not accept isotopes, stereochemistry, or lower-case atom labels.

Create a Workspace

Create a workspace and download the MX jarfile:

$ mkdir fptest
$ cd fptest
$ wget http://cloud.github.com/downloads/metamolecular/mx/mx-1.0-beta-2.jar

The Code

Create a file called 'FPTest.java' containing:

import java.io.BufferedReader;
import java.io.InputStreamReader;
import java.io.IOException;
import java.util.BitSet;
import com.metamolecular.mx.io.daylight.SMILESReader;
import com.metamolecular.mx.model.Molecule;
import com.metamolecular.mx.fingerprint.PathFingerprinter;

public class FPTest {
  private static PathFingerprinter fingerprinter = new PathFingerprinter();

  public static void main(String[] args) {
    try {
      BufferedReader in = new BufferedReader(new InputStreamReader(System.in));
      String str = "";
      while (str != null) {
          System.out.print("> ");
          str = in.readLine();
          processInput(str);
      }
    } catch (IOException e) {
    }
  }
  public static void processInput(String input) {
    if ("exit".equals(input)) {
      System.exit(0);
    }
    Molecule molecule = SMILESReader.read(input);
    BitSet fp = fingerprinter.getFingerprint(molecule);
    System.out.println(fp);
  }
}

Compile

$ javac -cp mx-1.0-beta-2.jar FPTest.java

Conclusions

A good fingerprint generator is a powerful item in any cheminformatics toolbox. This tutorial has shown a simple method for getting started with fingerprints using MX.